Article

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

2020-06-03

Abstract excerpt

<title>Abstract</title> <p>Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau pathology in AD by templated conversion of naive Tau in recipient cells into a pathologic...

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Literature Corpus work: 30238360-49b1-59bd-b3ae-149275794594
DOI: 10.21203/rs.3.rs-20919/v2

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