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Article

Lack of Evidence for a Substantial Rate of Templated Mutagenesis in B Cell Diversification.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2020

Fukuyama Julia, Olson Branden J, Matsen Frederick A

Abstract excerpt

BCR sequences diversify through mutations introduced by purpose-built cellular machinery. A recent paper has concluded that a "templated mutagenesis" process is a major contributor to somatic hypermutation and therefore Ig diversification in mice and humans. In this proposed process, mutations in the Ig locus are introduced by copying short segments from other Ig genes. If true, this would overturn decades of...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 32669310
DOI: 10.4049/jimmunol.2000092
PMCID: PMC7593666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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