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Article

Codon bias and plasticity in immunoglobulins.

Molecular biology and evolution - 1 Jun 1997

Kepler T B

Abstract excerpt

Immunoglobulin genes experience Darwinian evolution twice. In addition to the germline evolution all genes experience, immunoglobulins are subjected, upon exposure to antigen, to somatic hypermutation. This is accompanied by selection for high affinity to the eliciting antigen and frequently results in a significant increase in the specificity of the responding population. The hypermutation mechanism displays a...

Topics

Amino Acids
Binding Sites
Codon
Genetic Variation
Humans
Immunoglobulin Variable Region
Immunoglobulins
Linear Models
Models, Genetic
Molecular Sequence Data
Mutation
Selection, Genetic

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Identifiers

PMID: 9190065
DOI: 10.1093/oxfordjournals.molbev.a025803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9190065-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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