Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005

Martomo Stella A, Yang William W, Wersto Robert P, Ohkumo Tsuyoshi, Kondo Yuji, Yokoi Masayuki, Masutani Chikahide, Hanaoka Fumio, Gearhart Patricia J

Abstract excerpt

Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases. Indeed, humans deficient for DNA polymerase (pol) eta have decreased substitutions of A.T base pairs in variable and switch regions. To s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to DNA Repair

Share to Flow Cytometry

Share to Immunoglobulin Class Switching

Share to Immunoglobulin G

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 15939880
DOI: 10.1073/pnas.0501852102
PMCID: PMC1150827

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15939880-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.PMID 15939880Read ↗

DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation.Semantic proximity Read ↗

Emerging links between hypermutation of antibody genes and DNA polymerases.Semantic proximity Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.Semantic proximity Read ↗

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.Semantic proximity Read ↗

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.Semantic proximity Read ↗

Hijacked DNA repair proteins and unchained DNA polymerases.Semantic proximity Read ↗

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.Semantic proximity Read ↗

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.Semantic proximity Read ↗

Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody DiversificationSemantic proximity Read ↗

Altered spectra of hypermutation in DNA repair-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.