Article
Recombination-based mechanisms for somatic hypermutation.
Immunological reviews - 1 Apr 1998
Kong Q, Harris R S, Maizels N
Abstract excerpt
We review some experiments designed to test recombination-based mechanisms for somatic hypermutation in mice, particularly mechanisms involving templated mutation or gene conversion. As recombination and repair functions are highly conserved among prokaryotes and eukaryotes, pathways of mutation in microorganisms may prove relevant to the mechanism of somatic hypermutation. Escherichia coli initiates a...
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