Article
Lrrk2 modulation of Wnt signaling during zebrafish development.
Journal of neuroscience research - 1 Oct 2020
Wint Jinelle M, Sirotkin Howard I
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (lrrk2) are the most common genetic cause of Parkinson's disease. Difficulty in elucidating the pathogenic mechanisms resulting from disease-associated Lrrk2 variants stems from the complexity of Lrrk2 function and activities. Lrrk2 contains multiple protein-protein interacting domains, a GTPase domain, and a kinase domain. Lrrk2 is implicated in many cellular processes...
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