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Article

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.

Scientific reports - 29 May 2024

Wetzel Andrea, Lei Si Hang, Liu Tiansheng, Hughes Michael P, Peng Yunan, McKay Tristan, Waddington Simon N, Grannò Simone, Rahim Ahad A, Harvey Kirsten

Abstract excerpt

Parkinson's disease (PD) is a progressive late-onset neurodegenerative disease leading to physical and cognitive decline. Mutations of leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD. LRRK2 is a complex scaffolding protein with known regulatory roles in multiple molecular pathways. Two prominent examples of LRRK2-modulated pathways are Wingless/Int (Wnt) and nuclear factor of...

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Identifiers

PMID: 38811759
DOI: 10.1038/s41598-024-63130-8
PMCID: PMC11137013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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