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Article

LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.

Journal of neuroscience research - 1 Aug 2016

Prabhudesai Shubhangi, Bensabeur Fatima Zahra, Abdullah Rashed, Basak Indranil, Baez Solange, Alves Guido, Holtzman Nathalia G, Larsen Jan Petter, Møller Simon Geir

Abstract excerpt

Although mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic Parkinson's disease, their function is largely unknown. LRRK2 is pleiotropic in nature, shown to be involved in neurodegeneration and in more peripheral processes, including kidney functions, in rats and mice. Recent studies in zebrafish have shown conflicting evidence that removal of the LRRK2 WD40 domain may...

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Identifiers

PMID: 27265751
DOI: 10.1002/jnr.23754

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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