Article

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in model

2023-04-01

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is a progressive late-onset neurodegenerative disease leading to physical and cognitive decline. Mutations of leucine-rich repeat kinase 2 ( LRRK2 ) are the most common genetic cause of PD. LRRK2 is a complex scaffolding protein with known regulatory roles in multiple molecular pathways. Two prominent examples of LRRK2-modulated pathways are Wingless/Int (Wnt) and nuc...

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Literature Corpus work: f9bc3a68-7c19-5cfe-b120-62c3891a9f3e
DOI: 10.1101/2023.03.31.535090

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