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Article

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect.

PLoS genetics - 22 Apr 2010

Sheng Donglai, Qu Dianbo, Kwok Ken Hon Hung, Ng Seok Shin, Lim Adrian Yin Ming, Aw Sharon Siqi, Lee Charlie Wah Heng, Sung Wing Kin, Tan Eng King, Lufkin Thomas, Jesuthasan Suresh, Sinnakaruppan Mathavan, Liu Jianjun

Abstract excerpt

LRRK2 plays an important role in Parkinson's disease (PD), but its biological functions are largely unknown. Here, we cloned the homolog of human LRRK2, characterized its expression, and investigated its biological functions in zebrafish. The blockage of zebrafish LRRK2 (zLRRK2) protein by morpholinos caused embryonic lethality and severe developmental defects such as growth retardation and loss of neurons. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

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Source

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Identifiers

PMID: 20421934
DOI: 10.1371/journal.pgen.1000914
PMCID: PMC2858694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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