Article

Loss of <i>lrrk2</i> impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain

2017-05-23

Abstract excerpt

LRRK2 mutations are a major cause of Parkinson’s disease. Pathogenicity of LRRK2 loss-of-function is controversial, as knockout in rodents reportedly induces no brain-specific effects and knockdown studies in zebrafish are conflicting. Here we show that CRISPR/Cas9-engineered deletion of the ~60-kbp-long zebrafish lrrk2 locus elicits a pleomorphic, albeit transient brain phenotype in maternal-zygotic mutants (mzL...

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Literature Corpus work: 697b2bbb-ff52-5823-ae3a-748bb15d6f3a
DOI: 10.1101/140608

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