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Article

A sequential methodology for the rapid identification and characterization of breast cancer-associated functional SNPs.

Nature communications - 3 Jul 2020

Zhao Yihan, Wu Di, Jiang Danli, Zhang Xiaoyu, Wu Ting, Cui Jing, Qian Min, Zhao Jean, Oesterreich Steffi, Sun Wei, Finkel Toren, Li Gang

Abstract excerpt

GWAS cannot identify functional SNPs (fSNP) from disease-associated SNPs in linkage disequilibrium (LD). Here, we report developing three sequential methodologies including Reel-seq (Regulatory element-sequencing) to identify fSNPs in a high-throughput fashion, SDCP-MS (SNP-specific DNA competition pulldown-mass spectrometry) to identify fSNP-bound proteins and AIDP-Wb (allele-imbalanced DNA pulldown-Western...

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Identifiers

PMID: 32620845
DOI: 10.1038/s41467-020-17159-8
PMCID: PMC7334201

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