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Article

Identification of breast cancer associated variants that modulate transcription factor binding.

PLoS genetics - 1 Sept 2017

Liu Yunxian, Walavalkar Ninad M, Dozmorov Mikhail G, Rich Stephen S, Civelek Mete, Guertin Michael J

Abstract excerpt

Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants responsible for risk remain uncharacterized. The majority of GWAS-identified loci are enriched for non-coding single-nucleotide polymorphisms (SNPs) and defining the molecular mechanism of risk is challenging. Many non-coding causal SNPs are hypothesized to alter...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Regulatory Sequences, Nucleic Acid

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PMID: 28957321
DOI: 10.1371/journal.pgen.1006761
PMCID: PMC5619690

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