iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets.

Abstract excerpt

BACKGROUND: ChIP-seq provides new opportunities to study allele-specific protein-DNA binding (ASB). However, detecting allelic imbalance from a single ChIP-seq dataset often has low statistical power since only sequence reads mapped to heterozygote SNPs are informative for discriminating two alleles. RESULTS: We develop a new method iASeq to address this issue by jointly analyzing multiple ChIP-seq datasets....

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