Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum.

Research in veterinary science - 1 Oct 2020

Mammadova Najiba, Cassmann Eric, Greenlee Justin J

Abstract excerpt

Scrapie is a naturally occurring prion disease of sheep and goats that results in accumulation of the misfolded prion protein (PrPSc) and progressive neurodegeneration. After inoculation with classical scrapie isolate x124, susceptibility and incubation period are associated with valine at codon 136 (V136) of the prion protein: VRQ/VRQ had the shortest incubation periods, followed by VRQ/ARQ sheep, while ARQ/ARQ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Dose-Response Relationship, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to PrPSc Proteins

Share to Scrapie

Share to Sheep, Domestic

Source

Identifiers

PMID: 32610171
DOI: 10.1016/j.rvsc.2020.06.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum.PMID 32610171Read ↗

Characterization of a US sheep scrapie isolate with short incubation time.Semantic proximity Read ↗

Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains.Semantic proximity Read ↗

Transmission of classical scrapie using lymph node inoculum.Semantic proximity Read ↗

Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation.Semantic proximity Read ↗

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer.Semantic proximity Read ↗

Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie.Semantic proximity Read ↗

Minimum Effective Dose of Cattle and Sheep BSE for Oral Sheep Infection.Semantic proximity Read ↗

Pathogenesis, detection, and control of scrapie in sheep.Semantic proximity Read ↗

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.Semantic proximity Read ↗

The oral secretion of infectious scrapie prions occurs in preclinical sheep with a range of PRNP genotypes.Semantic proximity Read ↗

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years.Semantic proximity Read ↗

Genetic resistance to scrapie infection in experimentally challenged goats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.