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Article

Pathogenesis, detection, and control of scrapie in sheep.

American journal of veterinary research - 1 Jul 2020

Cassmann Eric D, Greenlee Justin J

Abstract excerpt

In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a prion (designated PrPSc). The normal cellular prion protein (PrPC) is encoded by an endogenous gene, PRNP, that is present in high concentrations within the CNS. Although a broad range of functions has been described for PrPC, its entire range of functions has yet to be fully elucidated. Accumulation of PrPSc results in...

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PMID: 32584178
DOI: 10.2460/ajvr.81.7.600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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