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Article

Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie.

PloS one - 1 Jan 2014

Jeffrey Martin, Martin Stuart, Chianini Francesca, Eaton Samantha, Dagleish Mark P, González Lorenzo

Abstract excerpt

The prion protein gene (Prnp) is highly influential in determining risk and susceptibility of sheep exposed to classical scrapie. Sheep homozygous for alanine at codon 136 and arginine at codons 154 and 171 (ARR/ARR) of the Prnp gene are historically considered to be highly resistant to classical scrapie, although they form a significant fraction of cases of atypical scrapie. To date, experimental transmission of...

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Identifiers

PMID: 24614120
DOI: 10.1371/journal.pone.0091026
PMCID: PMC3948952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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