Article
A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2005
Le Dur Annick, Béringue Vincent, Andréoletti Olivier, Reine Fabienne, Laï Thanh Lan, Baron Thierry, Bratberg Bjørn, Vilotte Jean-Luc, Sarradin Pierre, Benestad Sylvie L, Laude Hubert
Abstract excerpt
Scrapie in small ruminants belongs to transmissible spongiform encephalopathies (TSEs), or prion diseases, a family of fatal neurodegenerative disorders that affect humans and animals and can transmit within and between species by ingestion or inoculation. Conversion of the host-encoded prion protein (PrP), normal cellular PrP (PrP(c)), into a misfolded form, abnormal PrP (PrP(Sc)), plays a key role in TSE...
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