Deoxyribonucleotide pools as targets for mutagenesis by N-methyl-N-nitrosourea.

doi:10.1016/0027-5107(88)90079-6

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Article

Deoxyribonucleotide pools as targets for mutagenesis by N-methyl-N-nitrosourea.

Mutation research - 1 Jan 2000

Arecco A, Mun B J, Mathews C K

Abstract excerpt

This paper describes a biological test of the hypothesis that one or more components of the intracellular nucleotide pool represent a significant target for the mutagenic effects of alkylating agents. In other words, we ask whether mutagenesis can occur either through alkylation of susceptible nu...

Topics

Animals
Cell Line
Cricetinae
Deoxyadenosines
Deoxyguanine Nucleotides
Deoxyribonucleotides
Deoxyuridine
Methylnitrosourea
Mutation
Thymidine

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