Isolation of mutagen-sensitive Chinese hamster cell lines by replica plating.

doi:10.1385/1-59259-973-7:001

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Article

Isolation of mutagen-sensitive Chinese hamster cell lines by replica plating.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006

Zdzienicka Malgorzata Z

Abstract excerpt

Mutant rodent cell lines hypersensitive to DNA-damaging agents have provided a useful tool for the characterization of DNA repair pathways and have contributed to a better understanding of the mechanisms involved in the cellular responses to mutagenic treatment. Here we present a detailed description of how to isolate mutagen-sensitive mutants from hamster "wild-type" cell lines. First, cells are treated with...

Topics

Animals
CHO Cells
Cricetinae
Cricetulus
Drug Resistance
Mutagenesis
Mutagenicity Tests
Mutagens
Mutation
Radiation Tolerance
Radiation, Ionizing

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Open in PubMed

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PMID: 16673869
DOI: 10.1385/1-59259-973-7:001

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