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Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair

22 Feb 2021

Abstract excerpt

Gastric cancer is one of the most aggressive cancers, with a median survival of 12 months. This illustrates its complexity and the lack of therapeutic options, such as personalized therapy, because predictive markers do not exist. Thus, gastric cancer remains mostly treated with cytotoxic chemotherapies. In addition, less than 20% of patients respond to immunotherapy. TP53 mutations are particularly frequent in...

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PMID: 33671606
DOI: 10.3390/cancers13040916

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