Article
Genetic and immunohistochemical analyses of p53 independently predict regional metastasis of gastric cancers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2000
Shiao Y H, Palli D, Caporaso N E, Alvord W G, Amorosi A, Nesi G, Saieva C, Masala G, Fraumeni J F, Rice J M
Abstract excerpt
Either p53 gene mutation or immunohistochemical detection of p53 protein has not been consistently shown to have prognostic significance in human cancers, including gastric carcinomas. One hypothesis to explain this inconsistency is that some p53 mutations and p53 protein accumulation are not indicative of tumor progression. To test this hypothesis, we categorized p53 status in 105 gastric carcinomas according to...
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