Article
Pharmacological disruption of the Notch transcription factor complex.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2020
Lehal Rajwinder, Zaric Jelena, Vigolo Michele, Urech Charlotte, Frismantas Viktoras, Zangger Nadine, Cao Linlin, Berger Adeline, Chicote Irene, Loubéry Sylvain, Choi Sung Hee, Koch Ute, Blacklow Stephen C, Palmer Hector G, Bornhauser Beat, González-Gaitán Marcos, Arsenijevic Yvan, Zoete Vincent, Aster Jon C, Bourquin Jean-Pierre, Radtke Freddy
Abstract excerpt
Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies against Notch ligands and receptors, as well as small-molecule γ-secretase inhibitors (GSIs), have been developed to interfere with Notch receptor activation...
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