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Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

2023-10-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The oncogenic transcription factors STAT3, STAT5A and STAT5B are essential to steer hematopoiesis and immunity, but their enhanced expression and activation drives the development or progression of blood cancers, such as AML and NKCL. Current therapeutic strategies to inhibit STAT3/5 activity focus on blocking upstream tyrosine kinases, but frequently occurring...

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Literature Corpus work
580d3163-3449-5b19-bd53-23e7edb8b22f
DOI
10.21203/rs.3.rs-3443273/v1
Open publication

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Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphomaDOI 10.21203/rs.3.rs-3443273/v1
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