Article

Gamma-secretase inhibitor does not induce cytotoxicity in adult T cell leukemia cell lines despite NOTCH1 overexpression

2022-04-25

Abstract excerpt

<h4>Background: </h4> Activated mutations in Notch homolog 1, translocation-associated (Drosophila; NOTCH1) are driver oncogenes of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in other malignant neoplasms. We aimed to determine the function of NOTCH1 expression and...

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Literature Corpus work: fd482464-1d4e-52a9-954c-3c28e6d7166c
DOI: 10.21203/rs.3.rs-1542368/v1

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