Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.

Nature immunology - 1 Jul 2020

Choi Jinyong, Diao Huitian, Faliti Caterina E, Truong Jacquelyn, Rossi Meghan, Bélanger Simon, Yu Bingfei, Goldrath Ananda W, Pipkin Matthew E, Crotty Shane

Abstract excerpt

T follicular helper (TFH) cells are a distinct type of CD4+ T cells that are essential for most antibody and B lymphocyte responses. TFH cell regulation and dysregulation is involved in a range of diseases. Bcl-6 is the lineage-defining transcription factor of TFH cells and its activity is essential for TFH cell differentiation and function. However, how Bcl-6 controls TFH biology has largely remained unclear, at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Chromatin Immunoprecipitation Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Gene Regulatory Networks

Share to Germinal Center

Share to Proto-Oncogene Proteins c-bcl-6

Share to RNA-Seq

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 32572238
DOI: 10.1038/s41590-020-0706-5
PMCID: PMC7449381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.PMID 32572238Read ↗

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)Semantic proximity Read ↗

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanismsSemantic proximity Read ↗

Mechanisms of action of BCL6 during germinal center B cell developmentSemantic proximity Read ↗

Bcl6 mediates the development of T follicular helper cells.Semantic proximity Read ↗

B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and BeyondSemantic proximity Read ↗

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.Semantic proximity Read ↗

Bcl6: where too much complexity is barely enough.Semantic proximity Read ↗

Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model.Semantic proximity Read ↗

Roles of BCL6 in normal and transformed germinal center B cellsSemantic proximity Read ↗

Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function.Semantic proximity Read ↗

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.Semantic proximity Read ↗

T‐follicular helper cell differentiation and the co‐option of this pathway by non‐helper cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.