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Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)

1 Mar 2021

Abstract excerpt

Follicular helper T cells (T FH ) are essential B cell-help providers in the formation of germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity antibody-producing plasma cells, and production of memory B cells. The transcription factor (TF) B cell lymphoma 6 (Bcl6) is at the center of gene regulation in T FH biology, including differentiation and function, but how Bcl6 does...

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PMID: 33663954
DOI: 10.1016/j.it.2021.02.002

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