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Article

Bcl6 mediates the development of T follicular helper cells.

Science (New York, N.Y.) - 21 Aug 2009

Nurieva Roza I, Chung Yeonseok, Martinez Gustavo J, Yang Xuexian O, Tanaka Shinya, Matskevitch Tatyana D, Wang Yi-Hong, Dong Chen

Abstract excerpt

A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH)...

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Identifiers

PMID: 19628815
DOI: 10.1126/science.1176676
PMCID: PMC2857334

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Source receipt: pubmed, retrieved 7 Sept 2026.

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