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B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond

11 Oct 2024

Abstract excerpt

B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function. BCL6 is critical for germinal center (GC) formation and the development of high-affinity antibodies, with key roles in the generation and function of GC B cells, follicular helper T (Tfh) cells, follicular...

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PMID: 39456751
DOI: 10.3390/ijms252010968

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