Bcl6: where too much complexity is barely enough.

Abstract excerpt

Appropriate B-cell differentiation in response to antigen is fundamental to health. Central to the regulation of this process in circumstances of T-cell-dependent immune responses is the transcriptional repressor Bcl6, which is required for germinal centre (GC) formation and function. Within GCs, Bcl6 is already known to regulate many functions including proliferation, assessing DNA damage and terminal...

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