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Article

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

Cancer cell - 1 Sept 2007

Saito Masumichi, Gao Jie, Basso Katia, Kitagawa Yukiko, Smith Paula M, Bhagat Govind, Pernis Alessandra, Pasqualucci Laura, Dalla-Favera Riccardo

Abstract excerpt

The BCL6 proto-oncogene encodes a transcriptional repressor necessary for the development of germinal centers (GCs) and directly implicated in lymphomagenesis. Post-GC development of B cells requires BCL6 downregulation, while its constitutive expression caused by chromosomal translocations leads to diffuse large B cell lymphoma (DLBCL). Herein we identify a signaling pathway that downregulates BCL6 expression in...

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Share to CD40 Antigens
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factors

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-bcl-6

Share to Translocation, Genetic

Source

Identifiers

PMID: 17785208
DOI: 10.1016/j.ccr.2007.08.011

Genes

BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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