Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.

doi:10.1016/j.jbc.2021.101534

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Article

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.

The Journal of biological chemistry - 1 Feb 2022

Overway Emily M, Bosma Karin J, Claxton Derek P, Oeser James K, Singh Kritika, Breidenbach Lindsay B, Mchaourab Hassane S, Davis Lea K, O'Brien Richard M

Abstract excerpt

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). A common single-nucleotide polymorphism (SNP) in G6PC2, rs560887 is an important determinant of human FBG variability. This SNP has a subtle effect on G6PC2 RNA splicing, which raises the question as to whether nonsynonymous SNPs with a...

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PMID: 34954144
DOI: 10.1016/j.jbc.2021.101534
PMCID: PMC8800118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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