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Article

Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals.

Annals of nutrition & metabolism - 1 Jan 2010

Demirci F Y, Dressen A S, Hamman R F, Bunker C H, Kammerer C M, Kamboh M I

Abstract excerpt

BACKGROUND/AIMS: Fasting plasma glucose (FPG) levels correlate with cardiovascular disease and mortality in both diabetic and non-diabetic subjects. G6PC2 encodes a pancreatic islet-specific glucose-6-phosphatase-related protein and G6pc2-null mice were reported to exhibit decreased blood glucose levels. Two recent genome-wide association studies have implicated a role for G6PC2 in regulation of FPGlevels in the...

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Identifiers

PMID: 20029179
DOI: 10.1159/000268019
PMCID: PMC2855271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of a common G6PC2 variant with fasting plasma glucose levels in non-diabetic individuals.PMID 20029179Read ↗

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Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.Semantic proximity Read ↗

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose.Semantic proximity Read ↗

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.Semantic proximity Read ↗

HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2).Semantic proximity Read ↗

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.Semantic proximity Read ↗

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