Article
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
Human molecular genetics - 1 Nov 2009
Beer Nicola L, Tribble Nicholas D, McCulloch Laura J, Roos Charlotta, Johnson Paul R V, Orho-Melander Marju, Gloyn Anna L
Abstract excerpt
Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name GCKR)....
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