Article
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.
Diabetologia - 1 Apr 2007
Wang Y, Martin C C, Oeser J K, Sarkar S, McGuinness O P, Hutton J C, O'Brien R M
Abstract excerpt
AIMS/HYPOTHESIS: Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP, now known as glucose-6-phosphatase, catalytic, 2 [G6PC2]) has recently been identified as a major autoantigen in mouse and human type 1 diabetes. Strategies designed to suppress expression of the gene encoding G6PC2 might therefore be useful in delaying or preventing the onset of this disease. However, since the...
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