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Article

Effects of G6pc2 deletion on body weight and cholesterol in mice.

Journal of molecular endocrinology - 1 Apr 2017

Boortz Kayla A, Syring Kristen E, Pound Lynley D, Mo Huan, Bastarache Lisa, Oeser James K, McGuinness Owen P, Denny Joshua C, O'Brien Richard M

Abstract excerpt

Genome-wide association study (GWAS) data have linked the G6PC2 gene to variations in fasting blood glucose (FBG). G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit that forms a substrate cycle with the beta cell glucose sensor glucokinase. This cycle modulates the glucose sensitivity of insulin secretion and hence FBG. GWAS data have not linked G6PC2 to variations in body weight but we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28122818
DOI: 10.1530/JME-16-0202
PMCID: PMC5380368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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