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Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer’s disease

20 Feb 2025

Abstract excerpt

BACKGROUND: Blood biomarkers with prognostic accuracy for Alzheimer's disease (AD) are crucial for selecting at-risk individuals for interventions. Altered protein N-glycosylation has been implicated in several pathogenic pathways in AD and could be an early AD biomarker. METHODS: We developed a mass spectrometry-based method to simultaneously quantify 62 blood N-glycan structures in individuals with biological...

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PMID: 39983328
DOI: 10.1016/j.ebiom.2025.105598

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