Article

Human brain glycoform co-regulation network and glycan modification alterations in Alzheimer’s disease

2023-11-16

Abstract excerpt

Despite the importance of protein glycosylation to brain health, current knowledge of glycosylated proteoforms or glycoforms in human brain and their alterations in Alzheimer’s disease (AD) is limited. Here, we present a new paradigm of proteome-wide glycoform profiling study of human AD and control brains using intact glycopeptide-based quantitative glycoproteomics coupled with systems biology. Our study identifi...

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Literature Corpus work: d425c2cd-79e1-5e5c-a8b0-56a7f197bd26
DOI: 10.1101/2023.11.13.566889

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