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Article

Src-mediated phosphorylation of GAPDH regulates its nuclear localization and cellular response to DNA damage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Ci Shusheng, Xia Wen, Liang Weichu, Qin Lihong, Zhang Yilan, Dianov Grigory L, Wang Meina, Zhao Xingqi, Wu Congye, Alagamuthu Karthick Kumar, Hu Zhigang, He Lingfeng, Pan Feiyan, Guo Zhigang

Abstract excerpt

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme involved in energy metabolism. Recently, GAPDH has been suggested to have extraglycolytic functions in DNA repair, but the underlying mechanism for the GAPDH response to DNA damage remains unclear. Here, we demonstrate that the tyrosine kinase Src is activated under DNA damage stress and phosphorylates GAPDH at Tyr41. This phosphorylation of GAPDH...

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Identifiers

PMID: 32539222
DOI: 10.1096/fj.201902904RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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