Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.

Molecular and cellular probes - 1 Oct 2020

Zhao Lu, Li Ran, Qiu Jian-Zhong, Yu Jiang-Bo, Cao Yang, Yuan Rong-Tao

Abstract excerpt

Ionizing radiation (IR) confers a survival advantage in tongue squamous cell carcinoma (TSCC), however, IR resistance limits its efficacy. Although Yin Yang 1 (YY1) has been reported to play a role in genotoxic drug resistance by accelerating DNA repair, its role in TSCC radioresistance remains unclear. In this study, we examined YY1 mRNA and protein expression in human tongue cancer samples using qRT-PCR and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Transport

Share to PTEN Phosphohydrolase

Share to Radiation Tolerance

Share to Tongue Neoplasms

Share to Up-Regulation

Share to YY1 Transcription Factor

Source

Identifiers

PMID: 32334006
DOI: 10.1016/j.mcp.2020.101577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.PMID 32334006Read ↗

miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal PathwaySemantic proximity Read ↗

YAP1-TEAD4-DKK1 is an effective target for inhibiting radiation resistance in esophageal squamous carcinoma and activation of the pathway may be related to poor prognosis of patientsSemantic proximity Read ↗

YY1-<i>MIR372</i>-SQSTM1 regulatory axis in autophagySemantic proximity Read ↗

A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic TargetsSemantic proximity Read ↗

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivitySemantic proximity Read ↗

Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancerSemantic proximity Read ↗

Targeting the DNA Damage Response in OSCC with TP53 Mutations.Semantic proximity Read ↗

Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer TherapySemantic proximity Read ↗

PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell CarcinomaSemantic proximity Read ↗

YY1 downregulation underlies therapeutic response to molecular targeted agentsSemantic proximity Read ↗

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic targetSemantic proximity Read ↗

YY1 downregulation underlies therapeutic response to molecular targeted agentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.