Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect

5 Nov 2009

Abstract excerpt

BACKGROUND: The Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumour suppressor. Recent data have identified new functions of STAT1 associated with tumourigenesis and resistance to genotoxic stress, including ionizing radiation (IR) and chemotherapy. To investigate the mechanisms contributing to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19891767
DOI: 10.1186/1741-7015-7-68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effectPMID 19891767Read ↗

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumorsSemantic proximity Read ↗

Energy Restriction as an Antitumor Target of ThiazolidinedionesSemantic proximity Read ↗

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implicationsSemantic proximity Read ↗

CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing RadiationSemantic proximity Read ↗

ATM functions as a rheostat of metabolic stress in small-cell lung cancerSemantic proximity Read ↗

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug ResistanceSemantic proximity Read ↗

The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.Semantic proximity Read ↗

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Semantic proximity Read ↗

TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies.Semantic proximity Read ↗

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cellsSemantic proximity Read ↗

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells.Semantic proximity Read ↗

STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS InductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.