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Article

Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation.

The international journal of biochemistry & cell biology - 1 Oct 2010

Ventura Mireia, Mateo Francesca, Serratosa Joan, Salaet Ignasi, Carujo Sonia, Bachs Oriol, Pujol María Jesús

Abstract excerpt

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is considered a housekeeping glycolitic enzyme that recently has been implicated in cell signaling. Under apoptotic stresses, cells activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus. The GAPDH-Siah interaction depends on the integrity of lysine 227 in human GAPDH, being the mutant K227A unable to...

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Source

Identifiers

PMID: 20601085
DOI: 10.1016/j.biocel.2010.06.014

Genes

GAPDH

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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