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Article

Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2016

Sugatani Junko, Noguchi Yuji, Hattori Yoshiki, Yamaguchi Masahiko, Yamazaki Yasuhiro, Ikari Akira

Abstract excerpt

The human pregnane X receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism-related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutation at threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in vitro and...

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Identifiers

PMID: 26534988
DOI: 10.1124/dmd.115.066308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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