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Article

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

5 Jan 2017

Abstract excerpt

Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether c-Src contributes to metabolic reprogramming. Here we find that c-Src can interact with and phosphorylate hexokinases HK1 and HK2, the rate-limiting enzymes in glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity and thus enhances glycolysis. Mechanistically, c-Src...

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PMID: 28054552
DOI: 10.1038/ncomms13732

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