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Article

A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress.

The Journal of biological chemistry - 13 Feb 2004

Brown Victor M, Krynetski Eugene Y, Krynetskaia Natalia F, Grieger Dara, Mukatira Suraj T, Murti Kuruganti G, Slaughter Clive A, Park Hee-Won, Evans William E

Abstract excerpt

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein with glycolytic and non-glycolytic functions, including pro-apoptotic activity. GAPDH accumulates in the nucleus after cells are treated with genotoxic drugs, and it is present in a protein complex that binds DNA modifi...

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Share to Active Transport, Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exportin 1 Protein

Share to Glyceraldehyde-3-Phosphate Dehydrogenases

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Share to Receptors, Cytoplasmic and Nuclear

Share to Ribonucleoprotein, U5 Small Nuclear

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Identifiers

PMID: 14617633
DOI: 10.1074/jbc.M307071200

Genes

GAPDH
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14617633-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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