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Article

Viral vectored hepatitis C virus vaccines generate pan-genotypic T cell responses to conserved subdominant epitopes.

Vaccine - 6 Jul 2020

Donnison Timothy, von Delft Annette, Brown Anthony, Swadling Leo, Hutchings Claire, Hanke Tomáš, Chinnakannan Senthil, Barnes Eleanor

Abstract excerpt

BACKGROUND: Viral genetic variability presents a major challenge to the development of a prophylactic hepatitis C virus (HCV) vaccine. A promising HCV vaccine using chimpanzee adenoviral vectors (ChAd) encoding a genotype (gt) 1b non-structural protein (ChAd-Gt1b-NS) generated high magnitude T cell responses. However, these T cells showed reduced cross-recognition of dominant epitope variants and the vaccine has...

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Identifiers

PMID: 32532545
DOI: 10.1016/j.vaccine.2020.05.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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