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Article

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.

European journal of immunology - 1 Jan 2015

Kelly Christabel, Swadling Leo, Brown Anthony, Capone Stefania, Folgori Antonella, Salio Mariolina, Klenerman Paul, Barnes Eleanor

Abstract excerpt

Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(1073) and NS3(1446), and multiple variants for epitope NS3(1406) that occurred in >5% of genotype 1 and 3 sequences...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunospot Assay

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Source

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Identifiers

PMID: 25263407
DOI: 10.1002/eji.201444686
PMCID: PMC4784727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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