Article
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Cell host & microbe - 8 Jul 2020
Alix Eric, Godlee Camilla, Cerny Ondrej, Blundell Samkeliso, Tocci Romina, Matthews Sophie, Liu Mei, Pruneda Jonathan N, Swatek Kirby N, Komander David, Sleap Tabitha, Holden David W
Abstract excerpt
The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembrane protein of unknown biochemical...
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