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Article

MHC Class II Ubiquitination Regulates Dendritic Cell Function and Immunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2021

Wilson Kayla R, Jenika Devi, Blum Annabelle B, Macri Christophe, Xu Bangyan, Liu Haiyin, Schriek Patrick, Schienstock Dominik, Francis Lauren, Makota F Victor, Ishido Satoshi, Mueller Scott N, Lahoud Mireille H, Caminschi Irina, Edgington-Mitchell Laura E, Villadangos Jose A, Mintern Justine D

Abstract excerpt

MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4+ T cell immunity. Cell surface levels of MHC II loaded with peptide is controlled by ubiquitination. In this study, we have examined how MHC II ubiquitination impacts immunity using MHC IIKRKI/KI mice expressing mutant MHC II molecules that are unable to be ubiquitinated. Numbers of conventional DC (cDC) 1, cDC2 and plasmacytoid...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34599081
DOI: 10.4049/jimmunol.2001426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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