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Article

Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression.

The Journal of biological chemistry - 1 Jul 2021

Trenker Raphael, Wu Xinyu, Nguyen Julie V, Wilcox Stephen, Rubin Alan F, Call Matthew E, Call Melissa J

Abstract excerpt

Immune-stimulatory ligands, such as major histocompatibility complex molecules and the T-cell costimulatory ligand CD86, are central to productive immunity. Endogenous mammalian membrane-associated RING-CHs (MARCH) act on these and other targets to regulate antigen presentation and activation of adaptive immunity, whereas virus-encoded homologs target the same molecules to evade immune responses. Substrate...

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PMID: 34157285
DOI: 10.1016/j.jbc.2021.100900
PMCID: PMC8319528

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